1Duomo & Centro Storico
This is the heart of Florence, around the cathedral, Piazza della Signoria and a maze of narrow streets lined with churches, palaces and shops. Hotels here are mostly small city stays, classic properties and rooms in historic buildings. The big advantage is doing almost everything on foot, while the trade-off is more crowds and sometimes smaller or noisier rooms.
2Santa Maria Novella
Around Firenze Santa Maria Novella you are well placed if you are arriving by train or have an early departure. The area is still within walking distance of the historic centre and has a mix of simple hotels, reliable mid-range stays and larger city hotels. It feels more functional than romantic, but that often makes it an easy and relaxed choice.
3San Lorenzo
San Lorenzo sits between the station and the historic core, with Mercato Centrale and the Basilica di San Lorenzo as key landmarks. It suits travellers who want food halls, market stalls and plenty of casual places to eat, with hotels ranging from basic to stylish boutique stays. Expect more daytime bustle here, especially in peak season.
4Oltrarno & Santo Spirito
On the south side of the Arno, Florence feels slightly calmer and more residential, especially around Santo Spirito. You will find boutique hotels, small guesthouses and characterful stays in old houses, often with more personality than in the busiest central streets. The upside is charm and good evening atmosphere, the downside is slightly longer walks to some headline sights.
5Santa Croce
Santa Croce, east of the centre, combines major monuments with a youthful and energetic feel. Around the square and along the side streets you will find charming hotels, apartments in old buildings and smaller guesthouses. It works well if you want to stay central without sleeping right on the busiest shopping streets, though bar areas can be noisy.
6San Frediano
San Frediano, on the western side of Oltrarno, has a stronger neighbourhood feel, with craft workshops, small squares and fewer tourist-heavy streets. Accommodation tends to be small design hotels, B&Bs and stylish converted buildings. It is a good pick if you want a more local side of Florence, though the best-known sights are a little less immediate.