1Santa Cruz
Santa Cruz is the classic choice, a maze of narrow streets, small squares and old houses right in the historic core. This is where you will find many boutique hotels and characterful stays in restored buildings. The big advantage is doing almost everything on foot, though it can feel busy and taxis cannot always reach every doorstep.
2El Arenal
El Arenal sits between the cathedral and the Guadalquivir, with a slightly more open feel than Santa Cruz. It works well for tapas, evening walks by the river and easy access to the main sights. Hotels range from traditional city stays to solid mid-range options, though streets around popular dining areas can be noisy.
3Centro
For many travellers, Centro means the wider central area around shopping streets, plazas and major avenues. Stay here if you want shops, restaurants, landmarks and plenty of hotel choice close together. It is less romantic than Santa Cruz, but often more practical if you are arriving with luggage or like a lively city atmosphere.
4Triana
Triana, across the river, has a strong identity of its own and is closely linked with ceramics, flamenco and everyday neighbourhood life. It is often calmer at night than the old centre, with smaller hotels and apartment-style stays on residential streets. The trade-off is crossing the river for the headline sights, though that is usually a pleasant walk.
5Alameda de Hércules
Around Alameda de Hércules you are in a younger, looser part of Seville with lots of terraces, bars and a more alternative feel. Expect boutique stays, guesthouses and smaller hotels, often with a contemporary style. It is a good fit if you like going out in the evening, less so if you want especially quiet surroundings.
6Macarena
Macarena, north of the historic core, feels more residential and less tourist-focused. You will often find larger hotels and practical bases here, sometimes useful if you are driving or do not want to sleep in the thick of the crowds. The downside is a longer journey to the top sights than from the most central districts.